Synairgen shares bounce 30% as SNG001 shown to accelerate COVID-19 recovery
Positive data has been reported over time, in July, September, and now in November, in greater detail. The trial was double-blind, randomised, placebo-controlled, and sought to test the efficacy and safety of inhaled SNG001 as a therapy for patients hospitalised with COVID-19. Patients received the SNG001 or placebo by inhalation via a mouthpiece once daily for 14 days, with the primary endpoint being the change in clinical condition, using the WHO Ordinal Scale for Clinical Improvement.
Synairgen said that, based on the trial, “SNG001 was shown to be well tolerated and patients who received the drug had greater odds of improvement and recovered more rapidly”. Across the scale of clinical improvement, patients receiving the SNG001 were seen to have greater odds of improvement, and were also more likely to recover to “no limitation of activity” during treatment. Most notably: in the placebo control group, there were three deaths. In the SNG001 sample, there were none.
Speaking on the trial data, company Professor Tom Wilkinson, Professor of Respiratory Medicine at the University of Southampton and Lead Author, said:
“The results confirm our belief that interferon beta, a widely known drug approved for use in its injectable form for other indications, may have the potential as an inhaled drug to restore the lung’s immune response and accelerate recovery from COVID-19. This pH neutral, inhaled interferon beta-1a formulation (SNG001) provides high, local concentrations of the immune protein which boosts lung defences rather than targeting specific viral mechanisms. This might carry additional advantages of treating COVID-19 when it occurs alongside infection by another respiratory virus such as influenza or Respiratory Syncytial Virus that may well be encountered in the winter months.”
Following the announcement, Synairgen shares rallied by between 30% and 35%, up to more than 131p apiece at lunchtime on Friday 13/11/20. Until July, the company’s stock was trading for around half this price, but once the first SNG001 data was published, shares traded for as much as 246p.Nakama shares fall 20% as it states ‘working capital situation may deteriorate’
Its statement on Friday said that trading had been in line with management’s expectations, which had been adjusted once the practicalities of the pandemic came into full effect. However, it maintains that market conditions remain unfavourable, ‘particularly in light of a second wave’, which has prompted new national lockdowns and continued uncertainty.
Speaking on the deflated situation the company finds itself in, the Nakama statement read:
“It remains the Board’s view that as the various government support schemes are ended, the Company will face a number of trading and cashflow challenges and without access to additional capital the Group’s working capital situation may deteriorate. The Company’s largest shareholder has made it clear to the Board that they would not support a fundraise and would vote against the necessary shareholder resolutions to issue new shares.”
“As such and noting that the UK government support schemes are due to end in Q1 2021, the Board is now exploring a number of options for the Company and its businesses and further announcements will be made as and when appropriate.”
Following the announcement, the company’s shares were down by between 20% and 28% on Friday, down by around 22% at lunchtime – at 0.54p a share 13/11/20. This is still above its year-to-date nadir of 0.23p in March, but represents a climb-down from a recent uptick, with the company’s stock moving between 0.75p and 0.80p during October.Galliford Try reveals “excellent” start to financial year
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“Equities have moved lower this morning, as the vaccine bounce begins to fade across markets. After days of gains the rally in equities is beginning to slow down, as indices throughout Europe move into the red.”
“As enthusiasm about a vaccine begins to fade the FTSE 100 has lost ground, with a slowdown in the excited buying of hard-hit value names in sectors like travel, airlines, banks and others.”
Having soared on Monday, Rolls Royce has spent a few days shedding points, down by an additional 8% on Thursday. Similarly, having enjoyed an escape from a difficult year so far this week, oil blue chips such as BP and Shell followed the path of airlines, and watched their shares fall. Another issue has been a lack of positive developments – which is giving markets mixed messages. Mr Beauchamp added: “Political developments, or lack thereof, continue to have little impact, with the lack of any White House pronouncements helping to calm market nerves about the US political outlook.” Spreadex Financial Analyst, Connor Campbell, added on Brexit: “The mid-November deal deadline is almost upon us, with no agreement in site, and Boris Johnson’s government internally in chaos after the departure of director of communications, and Dominic Cummings ally, Lee Cain.” With global equities lacking a reason to celebrate, Eurozone indexes slipped, with the DAX down 1.2% and the CAC falling 1.5%. Slightly ahead of its European counterparts, the FTSE fell by 0.7%, lifted slightly by a sharp drop-off in Sterling. Notably, the Dow Jones was down by over 1.3%, and the Nasdaq fell by 0.8%. Even with vaccine jubilation fading – which should favour 2020’s growth stocks – big tech couldn’t muster up enough strength to lift US markets.